To observe the clinical effect of clearing heat and activating blood method combined with psychological counseling for chronic prostatitis. Methods:A total of 160 patients were randomly divided into control group and treatment group equally. Control group were given conventional antibiotic therapy, while the treatment group was treated with clearing heat and activating blood method combined with psychological counseling based on the conventional antibiotic therapy. We observed the effect after 30 days. Results: The effective rate of treatment group was 72%, while the control group was 62%. The effective rate of treatment group was significant higher than the control group (P<0.05). Conclusion: Clearing heat and activating blood method combined with psychotherapy has good effect in treating chronic prostatitis, and is superior to conventional antibiotic treatment.