To explore the effect of psychological intervention combined with acupuncture treatment on blood flow dynamics in peri-operative period and restlessness score in waking-up period for patients with urinary catheter after general anesthesia. Methods: Sixty patients who received Resection of Lumbar Intervertebral Disc (ASA, level I to II) under general anesthesia were randomly divided into psychological intervention group (group A, n=30) and control group (group B, n=30). Patients in both groups had urinary catheter after general anesthesia, and received perioperative nursery. Patients in group A received extra psychological intervention and acupuncture treatment after surgeries. The changes of heart rate (HR) and mean arterial blood pressure (MABP) 1 day before the surgery (T₁), before anesthesia(T₂), 15 minutes after extubation (T₃), 30 minutes after extubation (T₄) as well as the restlessness sore in waking-up period were observed and recorded. Results: Compared with T₃ and T₁, there were increase in HR and MABP for patients in both groups. During the phases of T₂, T₃ and T₄, the two groups showed significant differences (P<0.05). There were significant differences in restlessness scores in waking-up period between the two groups (P<0.05). Conclusion: Psychological intervention combined with acupuncture treatment could guarantee the stability of blood flow dynamics in peri-operative period and reduce the restlessness sore in waking-up period for patients with urinary catheter after general anesthesia.