To establish HPLC-ELSD method to determine the contents of notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Rb₁ and ginsenoside Rd in Fufang Danshen Tablets. Methods:C₁₈ columns were used with gradient elution of acetonitrile-water as mobile phase by flow rate of 1.0mL·min^-1. The column temperature was 25℃. The ELSD heater temperature was 50℃. Air flow rate was 1.5L·min^-1. Results: The measured peaks were completely separated from the other components in the peak. The linear ranges of notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Rb₁ and ginsenoside Rd were 5.14~102.80μg·mL^-1, 20.60~322.56μg·mL^-1, 40.24~402.40μg·mL^-1 and 10.06~100.60μg·mL^-1 respectively. The average recoveries of notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Rb₁ and ginsenoside Rd were 98.1%, 96.7%, 101.5% and 98.1% respectively. Conclusion: The method is simple and accurate with good robustness. It can be used for the determination of notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Rb₁ and ginsenoside Rd in Fufang Danshen Tablets.