External treatments of Traditional Chinese Medicine have advantages of rapid action and remarkable curative effect, however, to a certain extent, the further development of the treatment has been delayed by the imperfection of the theoretical system. Therefore, the authors put forward the concept of “meridian qi changes with time” on the basis of their years of clinical practice. The authors hold that the change of lunar years’ trend and the transition of host and guest climatic qi would affect the running of meridian qi in human body. We used this theory to adjust meridian qi, tonify deficiency and reduce excess according to time and qi running regulation to harmonize qi, blood, yin and yang, so as to adjust constitution.