| 引用本文:李涛 杜辉 洪兰 林颖娜 张锦花 汪卫东 高荣林.温胆宁心治疗失眠症（心胆气虚证）临床处方优化研究[J].世界中医药,2013,8(04):. |
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| 温胆宁心治疗失眠症（心胆气虚证）临床处方优化研究 |
| Clinical Observation on Prescription Optimization of Wendanningxin in Treating Insomnia(Syndrome Of Deficiency Of Heart And Gallbladder Qi) |
| 投稿时间：2013-02-21 |
| DOI： |
| 中文关键词: 失眠症/中医药疗法 匹兹堡睡眠质量指数量表 |
| English Keywords:Insomnia/ Chinese medical therapy Pitts burgh sleep quality index |
| 基金项目:“十一五”国家科技部重大新药创制项目（编号：2010ZX09102-215）“温胆宁心治疗精神性疾病——睡眠障碍的临床前研究”；“十一五”国家科技支撑计划重点项目（编号：2009BAI77B09） |
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| 中文摘要: |
| 目的：观察温胆宁心3个备选处方治疗失眠症的临床疗效及安全性，明确有效药味。方法：采用随机对照研究方法，将90例失眠症患者随机分为3组，即原方组、核心方组及核心方加减组，每组30例。疗程4周，应用匹兹堡睡眠质量量表（PSQI）评定临床疗效。结果:治疗4周后，3个备选处方在PSQI量表总分的组内比较均具有统计学意义（P<0.05）。3个处方有效率依次为原方55.56%，核心方57.14%，核心加减方61.54%，但各组差异无统计学意义（P>0.05）。结论：3个处方都有较好的镇静催眠作用，且其作用基本相当；核心加减方有效率在3组中最高，可作为优化处方备选之一。 |
| English Summary: |
| To observe clinical curative effects and safety of three candidate prescriptions of Wendanningxin for treating insomnia, and clarify its active ingredients.Methods:Random control trial was conducted to randomly divide 90 insomnia patients into three groups: YF group, HXF group, and HXJJF group. Treatment courses were four weeks, and clinical curative effects were assessed by PSQI.Results:After 4 weeks’ therapy, all of the three candidate prescriptions showed significant differences in PSQI total scores within each group (P<0.05). The effective rates of the three prescriptions were respectively YF group 55.56%, HXF group 57.14% and HXJJF group 61.54%, without showing significant differences among the three groups (P>0.05).Conclusion:All of three prescriptions show the function of hypnosis, and the therapeutic effects among them are essentially equivalent. HXJJF shows the highest effective rate, which maybe one of the best candidates for prescription optimization. |
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