世界中医药

目的：观察血府逐瘀汤加减治疗伴抑郁症的反流性食管炎的临床疗效。方法：将60例伴抑郁症的RE患者随机分为治疗组30例和对照组30例。治疗组采用血府逐瘀汤加减治疗，对照组采用奥美拉唑、多潘立酮片、氟哌噻吨美利曲辛片治疗。临床疗效根据症状积分、Zung抑郁自评量表（SDS）积分变化、内镜下疗效比较评定。结果：治疗4周后，与治疗前比较临床症状积分及抑郁症积分，治疗组明显优于对照组（P<0.05）；8周后2组总疗效无统计学意义（P>0.05）。停药半年后随访，治疗组的总体疗效优于对照组（P<0.05）。结论：血府逐瘀汤加减治疗伴抑郁症的反流性食管炎见效快，疗效满意，且复发率低。

English Summary:

To observe the clinical curative effect of modified Xuefu Zhuyu Decoction in treating reflux esophagitis (RE) accompanied by depression.Methods:Sixty patients suffered depression RE were randomly divided into treatment group(30 cases)and control group(30 cases). Patients in treatment group were given modified Xuefu Zhuyu Decoction, while the control group treated patients with omeprazole, domperidone, flupentixol　and　melitracen　tablets. Clinical curative effect was evaluated according to the changes of score in clinical symptoms and zung Self Rating Depression Scale(SDS) and observation under gastro scope.Results:Four weeks after treatment, the clinical symptom score and depression points of the treatment group were significantly better than that of the control group (P<0.05); eight weeks after treatment, there were no significant difference between the two groups on the total therapeutic effect (P>0.05). The follow up conducted six month after drug withdrawal showed better total therapeutic effect in treatment group (P<0.05).Conclusion:Modified Xuefu Zhuyu Decoction has instant and satisfactory therapeutic effect along with low recurrence rate in treating reflux esophagitis accompanied by depression.

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