世界中医药

目的：观察荆花胃康胶丸联合雷贝拉唑、克拉霉素、阿莫西林“三联”疗法对消化性溃疡(PU)的临床疗效及根除幽门螺旋杆菌(HP)的效果。方法：经胃镜检查确诊为PU A1或A2期并符合寒热错杂并气滞血瘀证，经C14-尿素呼气试验测定HP感染阳性患者300例，随机分为三组，分别是荆花组、四联组和三联组，每组各100例患者。三联组给予雷贝拉唑，疗程6周；克拉霉素、阿莫西林，疗程1周。四联组在三联组基础上加服枸橼酸铋钾，疗程2周。荆花组在三联组基础上加服荆花胃康胶丸，疗程6周。观察治疗后溃疡愈合率及HP根除情况。结果：荆花组、三联组和四联组溃疡愈合率分别为93%、88%和90%，三联组与荆花组比较有统计学意义(P<0.05)，四联组与荆花组比较无统计学意义(P>0.05)；HP清除率分别为95%、86%和88%，荆花组与其余2组比较均有统计学意义(P<0.05)。结论：荆花胃康胶丸联合“三联”疗法治疗PU不仅具有较好的溃疡愈合率，而且可提高HP清除率。

English Summary:

To investigate efficacy of Jinghua Weikang Capsules combined with amoxicillin and clarithromycin, ray Bella, "triple" therapy on peptic ulcer (PU) and on clearance of Helicobacter pylori (HP).Methods:Gastroscopy confirmed PU A1 or A2 phase patients, meeting cold heat complex, Qi stagnant blood stasis, had HP tested positive by the C14 urea breath test, were randomly divided into three groups, Jinghua group, quadruple and triple group, 100 cases in each group. Triple group received ray Bella azole capsule for 6 weeks; clarithromycin extended release tablets for 1 week. On top of medications, Quadruple group received Bismuth Potassium Citrate Granules for 2 weeks, and Jinghua group recieved Jinghua Weikang Capsules for 6 weeks. Ulcer healing rate and Helicobacter pylori clearancewere observed.Results:Healing rates of Jinghua group, triple and quadruple group were 93%,88% and 90%, there was significant difference between triple group and Jinghua group (P<0.05), quadruple group and Jinghua group showed no significant difference (P>0.05); H.pylori clearancerates were 95%,86% and 88% respectively and Jinghua group had significant differences with other two groups (P<0.05).Conclusion:Jinghua Weikang Capsule combined with ray Bella, clarithromycin, amoxicillin is effective to heal peptic ulcers and improve helicobacter pylori clearance.

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