世界中医药
文章摘要
引用本文:吴文静 王世东 周 鑫 王颖辉 吕仁和.基于因子分析的痛风病病机研究[J].世界中医药,2013,8(05):.  
基于因子分析的痛风病病机研究
Study on Pathogenesis of Gout Based on Factor Analysis
投稿时间:2013-04-10  
DOI:10.3969/j.issn.1673-7202.2013.05.004
中文关键词:  病机研究  痛风  因子分析  证素研究  
English Keywords:Study on pathogenesis  Gout  Factor analysis  TCM syndrome elements
基金项目:首发基金重点支持项目(编号:SF-2009-Ⅱ-06);国家中医药管理局吕仁和名医传承工作室建设项目
作者单位
吴文静1 王世东2 周 鑫1 王颖辉3 吕仁和4 1 北京中医药大学北京100029 2 北京中医药大学东直门医院中医内分泌病学科北京100700 3 王府中西医结合医院北京100049 4 北京市“薪火传承”吕仁和名医工作站北京100700 
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中文摘要:
      目的:探讨痛风病无症状性高尿酸血症期、急性关节炎期和间歇期中医证素分布情况,总结归纳痛风病的病机。方法:本研究通过对100例无症状性高尿酸血症期患者、69例痛风急性期患者和72例痛风间歇期患者进行中医证候问卷调查,应用因子分析多元统计分析方法归纳各期证素分布情况。结果:无症状性高尿酸血症期的主要证素为湿热证(36%)、阴虚证(30%)、痰湿证(19%)、气虚证(9%)及阳虚证(6%)。急性关节炎期主要证素为痰湿证(29%)、湿热证(26.1%)、阴虚证(23.2%)、阳虚证(11.6%)、血瘀证(7.2%)及气虚证(2.9%)。间歇期主要证素为阴虚证(36.1%)、湿热证(23.6%)、阳虚证(18.1%)、痰湿证(15.3%)、气虚证(9%)。结论:痛风为虚实夹杂之证,早期及急性期以痰湿热为主,反复发作,病情迁移,则正虚加重,以阴虚、阳虚为主。
English Summary:
      To explore the distribution of syndrome elements during asymptomatic hyperuricemia phase of gout, urarthritis phase and intermission phase of gout, so as to conclude the pathogenesis of gout. Methods:Questionnaire survey on TCM syndrome was conducted on 100 patients on the phase of asymptomatic hyperuricemia, 69 patients on urarthritis phase and 72 patients on intermission phase of gout. Factor analysis was adopted for the distribution of syndrome elements. Results:The major syndrome elements of asymptomatic hyperuricemia of gout were dampness heat syndrome (36%), yin deficiency syndrome (30%), phlegm dampness syndrome (19%), qi deficiency syndrome (9%), yang deficiency syndrome (6%). The major syndrome elements of urarthritis were phlegm dampness syndrome (29%), dampness heat syndrome (26.1%), yin deficiency syndrome (23.2%), yang deficiency syndrome (11.6%), blood stasis syndrome (7.2%) and qi deficiency syndrome(2.9%). The major syndrome elements of intermission phase of gout were yin deficiency syndrome (36.1%), dampness heat syndrome (23.6%), yang deficiency syndrome (18.1%), phlegm dampness syndrome (15.3%), qi deficiency syndrome (9%). Conclusion: Gout is mixed with deficiency and excess. The major syndromes of early and acute stage of gout are phlegm, dampness and heat. It is repetitive and easy to transfer to yin deficiency and yang deficiency.
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