| 引用本文:佟 颖 孟 洁 金 汤 王 博 杨福庆 苏冠霞 杜丽坤 王育红 王 石.痹宁胶囊对急性痛风性关节炎大鼠模型IL-1及MMP-9的研究[J].世界中医药,2013,8(05):. |
|
| 痹宁胶囊对急性痛风性关节炎大鼠模型IL-1及MMP-9的研究 |
| Study on Effect of Bining Capsule on Levels of IL-1 and MMP-9 of Rats with Acute Gouty Arthritis |
| 投稿时间：2012-10-31 |
| DOI：10.3969/j.issn.1673-7202.2013.05.023 |
| 中文关键词: 急性痛风性关节炎 @ 痹宁胶囊 足跖容积 IL-1 滑膜组织 基质金属蛋白酶-9 |
| English Keywords:Bining Capsule Acute gouty arthritis Paw volume (IL-1 Synovial tissue Matrix metalloproteinase -9 (MMP-9) |
| 基金项目:黑龙江中医药大学科研基金项目(编号：200522) |
|
| 摘要点击次数: 1307 |
| 全文下载次数: 1354 |
| 中文摘要: |
| 目的：观察痹宁胶囊对急性痛风性关节炎大鼠模型滑膜组织的抗炎作用。方法：将Wistar大鼠60只，雌雄各半，造模成功后，随机分为空白组、模型组、西药组、中药高剂量组、中药中剂量组、中药低剂量组，药物干预7 d。于造模前、造模后、治疗结束处死前测定大鼠右侧足踝关节容积及血白细胞介素-1(Interleukin-1，IL-1)，并在处死后将右侧踝关节滑膜组织做常规HE染色，光镜下观察病理滑膜组织并评分。结果：痹宁胶囊有利于大鼠受损的滑膜组织炎症修复，优于西药组，以中药高剂量组为佳。结论：痹宁胶囊对急性痛风性关节炎大鼠模型滑膜组织有明显的抗炎作用。 |
| English Summary: |
| To observe the anti-inflammatory effect of Bin ing Capsule on syno-vial tissue of rats with acute gouty arthritis. Methods:After a successful modeling of 60 half male and half female Wistar rats, they were randomly divided into blank control group，model group, Western medicine group, Chinese medicine high dose group, Chinese medicine middle dose group, and Chinese medicine low dose group. They were all intervened by drugs for 7 days. The right ankle volume of rats and the level of Interleukin-1(IL-1) before modeling, after modeling and the end of treatment were measured. Besides, the synovial tissue of right ankles were put in routine HE staining after the death of rats, in order to observe and score the pathological synovial tissue through light microscopy. Results:Bining Capsule was beneficial to the repair of inflammation of damaged synovial tissue in rats, better than Western medicine group, and the Chinese medicine high dose group showed the best effect. Conclusion: Bining Capsule has significant anti-inflammatory effect in synovial tissue of rats model with acute gouty arthritis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
