| 引用本文:江丽杰1 胡镜清2，3 易丹辉4 陈 倩4 刘保延5.缺血性中风病中医证候要素动态变化与NIHSS评分变化相关性的贝叶斯网络分析[J].世界中医药,2013,8(06):. |
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| 缺血性中风病中医证候要素动态变化与NIHSS评分变化相关性的贝叶斯网络分析 |
| Bayesian Network Analysis of Correlation between TCM Syndrome Dynamic Changes and NIHSS Scores of Ischemia Stroke |
| 投稿时间：2013-05-23 |
| DOI：10.3969/j.issn.1673-7202.2013.06.006 |
| 中文关键词: 缺血性中风病 证候 结局评价 贝叶斯网络 美国国立卫生院卒中量表 |
| English Keywords:Ischemia stroke TCM syndrome Outcome evaluation Bayesian network NIHSS |
| 基金项目:国家自然科学基金课题（编号：30873460），构建表征证候动态变化纵向结局评价指标的示范研究；中医药行业科研专项课题（编号：201107006），中医慢病临床科研体系及其成果转化应用模式研究 |
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| 中文摘要: |
| 目的：探讨缺血性中风病中医证候要素动态变化与NIHSS评分变化之间的关系。方法：以379例缺血性中风病临床数据为基础，在5个不同时点（0d、3d、14d、28d、3m）采集《中风病辨证诊断标准》中风、火、痰、瘀、气虚、阴虚阳亢6个证候要素的评分和《美国国立卫生院卒中量表》(NIHSS)评分，运用贝叶斯网络分析其相关性。结果：0～3d时，NIHSS评分改善，证候要素痰、瘀、阴虚阳亢和气虚的改善概率分别为0.809、0.896、0.934、0.961；3～14d时，火热、瘀、痰、阴虚阳亢和气虚的改善概率分别为0.546、0.843、0.895、0.962、0.944；14～28d时，火热、痰、阴虚阳亢和气虚的改善概率分别为0.53、0.815、0.966、0.987；28d至3m时，风、火热、瘀、痰、阴虚阳亢和气虚的改善概率分别为0.507、0.667、0.854、0.505、0.905、0.914，与NIHSS呈现出明显的正向关系。结论：缺血性中风病的NIHSS评分变化在不同时点均有多个证候要素评分与之相关，其相关程度随时间动态演变。 |
| English Summary: |
| To investigate the correlation between TCM syndrome dynamic changes and NIHSS scores of ischemia stroke. Methods: The patients with ischemia stroke ( n = 379 ) were selected and their scores of six syndrome factors (wind， fire， phlegm， stasis， qi-deficiency and hyperactivity of yang due to yin-deficiency) according to the Diagnostic Standard of Syndrome Differentiation of Stroke and the National Institutes of Health Stroke Scale (NIHSS) at 5 different time points （0d， 3d ，14d， 28d ， 3m）were recorded respectively. The correlation between syndrome factors and NIHSS scores at different time points were studied by using the method of Bayesian network. Results: NIHSS were improved during 0d-3d， and the improvement rate of phlegm， stasis， hyperactivity of yang due to yin-deficiency and qi-deficiency were respectively 0.809， 0.896， 0.934， 0.961; during 3d-14d ， the improvement rate of fire， stasis， phlegm， hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.546， 0.843， 0.895， 0.962， 0.944; during 14d-28d ， the improvement rate of fire， phlegm， hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.53， 0.815， 0.966， 0.987; during 28d-3m ，the improvement rate of wind， fire， stasis， phlegm， hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.507， 0.667， 0.854， 0.505， 0.905， 0.914. Conclusion: There is a correlation between TCM syndrome factors manifestations and NIHSS scores in ischemia stroke at different time points， and the correlation degree changes dynamically over time. |
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