To investigate the correlation between TCM syndrome dynamic changes and NIHSS scores of ischemia stroke. Methods: The patients with ischemia stroke ( n = 379 ) were selected and their scores of six syndrome factors (wind， fire， phlegm， stasis， qi-deficiency and hyperactivity of yang due to yin-deficiency) according to the Diagnostic Standard of Syndrome Differentiation of Stroke and the National Institutes of Health Stroke Scale (NIHSS) at 5 different time points （0d， 3d ，14d， 28d ， 3m）were recorded respectively. The correlation between syndrome factors and NIHSS scores at different time points were studied by using the method of Bayesian network. Results: NIHSS were improved during 0d-3d， and the improvement rate of phlegm， stasis， hyperactivity of yang due to yin-deficiency and qi-deficiency were respectively 0.809， 0.896， 0.934， 0.961; during 3d-14d ， the improvement rate of fire， stasis， phlegm， hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.546， 0.843， 0.895， 0.962， 0.944; during 14d-28d ， the improvement rate of fire， phlegm， hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.53， 0.815， 0.966， 0.987; during 28d-3m ，the improvement rate of wind， fire， stasis， phlegm， hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.507， 0.667， 0.854， 0.505， 0.905， 0.914. Conclusion: There is a correlation between TCM syndrome factors manifestations and NIHSS scores in ischemia stroke at different time points， and the correlation degree changes dynamically over time.