| 引用本文:刘恩顺 刘 伟 孙增涛 苏景深 关 鹏.清肺消炎丸对COPD大鼠肺组织MMP-9和TIMP-1表达的影响[J].世界中医药,2013,8(06):. |
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| 清肺消炎丸对COPD大鼠肺组织MMP-9和TIMP-1表达的影响 |
| Effect of Qingfei Xiaoyan Pills on the Expression of MMP-9 and TIMP-1 in the Lung Tissue of COPD Rats |
| 投稿时间：2013-01-03 |
| DOI：10.3969/j.issn.1673-7202.2013.06.021 |
| 中文关键词: 清肺消炎丸 慢性阻塞性肺疾病 急性发作期 MMP-9 TIMP-1 |
| English Keywords:Qingfei Xiaoyan Pills COPD Acute exacerbation MMP-9 TIMP-1 |
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| 中文摘要: |
| 目的:观察清肺消炎丸对COPD大鼠肺组织中基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶组织抑制因子-1(TIMP-1)表达的影响。方法:将30只Wistar大鼠，随机分为3组，正常对照组、COPD模型组和清肺消炎丸组，除正常对照组外，采用烟熏及内窥镜下气管滴入内毒素方法制作COPD模型，造模成功后分别治疗7 d，观察各组肺组织中MMP-9和TIMP-1表达变化。结果:模型组大鼠肺组织MMP-9和TIMP-1的表达与空白组相比明显增强(P<0.05)，中药治疗组大鼠肺组织MMP-9和TIMP-1水平比模型组减低(P<0.05)。结论:清肺消炎丸具有抑制COPD大鼠肺组织中MMP-9及TIMP-1的表达，改善MMP-9/TIMP-1比例失衡，从而防治该病气道重塑的作用。 |
| English Summary: |
| To observe the effect of Qingfei Xiaoyan Pills on the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) in the lung tissue of COPD Rats. Methods:Thirty Wistar rats were divided into 3 groups randomly， normal control group， COPD model group， Qingfei Xiaoyan Pills group. Except for the normal control group， we made the COPD model by smudging plus intratracheal instillation of LPS under endoscopy， and treated them separately for 7days. Then we observed the change of MMP-9 and TIMP-1 expression in the lung tissue. Results:The MMP-9and TIMP-1 expression in the lung of COPD model group were obviously increased than those of control group(P<0.05)， the MMP-9 and TIMP-1 of Qingfei Xiaoyan Pills group were lower than those of model group (P<0.05).Conclusion: Qingfei Xiaoyan Pills could inhibit the expression of MMP-9 and TIMP-1 in the lung in COPD rats， improve the MMP-9 / TIMP-1 imbalance， thus playing a role in preventing and treating airway remodeling in COPD. |
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