To observe the effects of preictal intervention of phlegm and stasis resolving and liver soothing method on NGF-TrkA signaling pathway of neurogenic inflammation of murine model of asthma. Methods: The asthmatic BALB/c mice model were established through being sensitized by intra-peritoneal injection of 10% OVA/AL(OH)3 solution， and activated by 5% ovalbumin solution. Intervention started before activation， and lung homogenate was obtained after activation. NGF and TrkA concentration in BALF were examined by ELISA， and the protein expression of NGF and TrkA concentration in lung tissue homogenate were detected by western blot. Results: In asthmatic model BALB/c mice， NGF and TrkA concentration significantly increased (P<0.01)， the protein expression significantly increased (P<0.05，P<0.01).The NGF、TrkA concentration of all intervention groups decreased (P<0.01)， while DXM showed a better effect than the other two intervention groups (P<0.01). The NGF protein expression in PCF and SGPCF group decreased significantly compared with model group(P<0.01)，while that of DXM group was similar to model group(P>0.05).TrkA protein expression of PCF and SGPCF group were lowered(P<0.05，P<0.01)，PCF group had a similar effect on NGF and TrkA with DXM， while SGPCF showed a significantly better effect than DXM(P<0.05)，but the differences between PCF and SGPCF group had no statistical significance(P>0.05). Conclusion: Preictal intervention of phlegm and stasis resolving and liver soothing method can decrease the increased concentration and protein expression of NGF and TrkA. The effect is generally similar to phlegm and stasis resolving and qi regulating method， and better than dexamethasone， which indicates that preictal intervention of phlegm and stasis resolving and liver soothing method has a definite effect on the NGF-TrkA pathway of neurogenic inflammation of murine model of asthma.