To investigate the clinical effect of lumbar manipulation of tuina combined with modified Xuefu Zhuyu Decoction in treating acute lumbar sprain clinical. Methods:One hundred and twenty six patients of acute lumbar sprain were randomly divided into control group and treatment group. The 63 patients in control group were given lumbar manipulation of tuina， while the patients in treatment group received modified Xuefu Zhuyu decoction apart from lumbar manipulation of tuina. Results:The total effective rate in treatment group and control group were respectively 98.41% and 85.71%， which showed significant differences (P<0.05); compared with the baseline data， the VAS score on the 4th day and 10th day of the treatment in both of the groups showed significant decrease， while better improvement was showed in the treatment group (P<0.05); there were no significant differences when comparing the VAS score on the 4th day of the treatment group with VAS score on the 10th day of the control group (P>0.05). There were no adverse reactions occurred in both groups during the treatment. Conclusion: Lumbar manipulation of tuina combined with modified Xuefu Zhuyu Decoction in treating acute lumbar sprain could reconcile blood， promote blood circulation， remove blood stasis， relieve muscle pain， rapidly relieve lumbar pain with satisfactory curative effect and safety which is worth generalizing.