To observe the therapeutic effect of Qiliqiangxin capsule treating heart failure (HF) after delayed PCI for acute myocardial infarction. Methods: Forty patients who had heart failure after delayed PCI for acute myocardial infarction were randomly divided into two groups. The 20 patients in the control group were given standard anti-HF treatment， and the other 20 patients in the treatment group received extra administration of qiliqiangxin capsule. Clinical therapeutic effect and LVEF were observed after three months of treatment. Results: The total effective rates showed statistically significant differences between the two groups (P<0.05). The walking test results in 6 minutes and LVEF in treatment group were significantly higher than that of the control group (P<0.05). Conclusion: Qiliqiangxin capsule treating heart failure (HF) after delayed PCI for acute myocardial infarction shows certain therapeutic effect in improving heart function.