To explore the clinic effect of syndrome differentiation of traditional Chinese Medicine combined with chemotherapy in treating late gastric cancer. Methods:One hundred patients suffered from late gastric cancer admitted to our hospital from Jan 2006 to Aug 2012 were randomly divided into treatment group and control group. Patients in the treatment group were given syndrome differentiation of traditional Chinese Medicine combined with chemotherapy while the control group only applied chemotherapy. Results:There were significant difference in the total effective rate between the treatment group and control group (42.00% compared with 34.00%, P<0.05); the Karnofsky score in treatment group was significantly higher than that in control group(P<0.05); the survival rates of patients 6 month and one year after treatment in treatment group were respectively 76.00% and 44.00%, which were both higher and significantly different compared with the control group (36% and 10%). Conclusion: Syndrome differentiation of traditional Chinese Medicine combined with chemotherapy treating late gastric cancer could significantly strengthen the tolerance of chemotherapy, increase survival period, improve the quality of life, so it is worth generalizing clinically.