To study the influence of Danhong injection combined with western medicine on the nerve conduction velocity and nerve growth related factors of diabetic peripheral polyneuropathy. Methods:Forty-one patients with diabetic peripheral polyneuropathy who were treated with routine western medicine in our hospital from July 2010 to September 2012 were selected into control group, and another 41 patients who were treated with Danhong injection combined with western medicine at the same time were selected into treatment group, then the nerve conduction velocity and nerve growth related factors of patients in the two groups before and after the treatment at tenth and twentieth day were compared. Results:The medium nerve and common peroneal nerve conduction velocity of patients in treatment group after the treatment at tenth and twentieth day were all higher than those of control group, and serum MBP were lower than those of control group, serum BDNF,NGF and IGF-1 were all higher than those of control group, (P<0.05) there were all significant differences between the two groups. Conclusion: The Danhong injection combined with western medicine can effectively improve the nerve conduction velocity and nerve growth related factors of patients with diabetic peripheral polyneuropathy, so it plays an active clinical role in improving the nerve function of patients.