To observe the clinical effect of self made Xiao Zhi Prescription treating non-alcoholic steatohepatitis. Methods: Eighty non-alcoholic steatohepatitis patients admitted to our department were randomly divided into treatment group and control group. Patients in control group were given western medicine, and patients in treatment group received extra TCM treatment of Xiao zhi prescription. The total therapeutic effect, and lab parameters changes were observed. And follow-up was conducted 6 month after the treatment to see the relapse rate. Results: The total effective rate in treatment group was 95.24%, which was significantly better than the 78.95% in the control group (P<0.05); the improvement of ALT, AST, GGT, TG in treatment group were significantly better than that of the control group (P<0.05); the recurrence rate of the control group was 24.14%, while that in the treatment group was 5.00%, which showed significant differences (P<0.05). Conclusion: Xiao Zhi Prescription treating NASH has good efficacy and low recurrence rate with no obvious adverse reactions, which is worthy of clinical application.