To evaluate the efficacy and safety of Biyan Ning Granules in treating acute sinusitis in adults. Methods: Totally 122 patients were enrolled into the study, aged from 18 to 70. The dosages of Biyan Ning Granules were 15 g twice daily, the duration of treatment was 20 days. Symptoms and physical signs were evaluated before and after treatment, AEs if any would be reported. Results: A clinical response of “cure” and ”improved” were 15.5% and 70.7% of patients respectively. No incidence of adverse events was reported. Conclusion: Biyan Ning Granules is effective for treatment of acute sinusitis.