This paper discusses the safety issues of acupotomology which has received controversial attention since its origin. It briefly analyzes the significance of safety for acupotomology itself, and points out that safe procedure of acupotomology would be a basic guarantee for its development and fundamental requirement for its medical quality control. It also believes that solving safety issue is the primary strategy for the development of acupotomology, and establishing relevant standards on safe procedure is a necessary step. Also, this paper briefly introduces “Handbook of Clinical Safety Operation of Acupotomology” which is a first monograph on acupotomology safety and provides many safe procedures for clinical personnel.