Due to rapidly developing systems biology and its profound impact on pharmacology, an emerging trans-disciplinary branch of study is taking shape, that is systems pharmacology (SP). Theory and methodology of systems pharmacology are not yet mature, let alone adopt the thinking and theories of SP to Chinese Medicine research. Based on new advancements of SP and practical research experience, present research introduced how to integrate pharmacokinetics, pharmacodynamics, networks, biology, and systems analysis to form a system model for forecast and validation of TCM pharmacology and pharmacodynamics, in order to provide new methodology for evaluating drug-human interactions, R&D of new drugs, target identification, new therapeutic strategies and so on. In the end the paper introduced the newly developed TCM systems pharmacology database and analysis platform.