As a magical medicinal plant in China’s treasure house of Chinese medicine resources, Astragalus has been applied as medicine for over 2000 years. Its main medicinal ingredient APS plays an important pharmacological role in immune regulation in treating a variety of diseases on the basis research and clinical applications. However, current studies on clinical compatibility and monomer potency of APS are still on the exploratory stage, so the use of advanced technological methods, the development of new targets of APS and efficacy studies should be strengthened.