To observe the effect of moxa somke with different concentrations on blood microcirculation and provide reference on security of moxa smoke in clinic. Methods: A total of 168 rats were randomly divided into 4 groups ，42 in each group. Rats in control group， low concentration goup， medium concentration group， high concentration group were respectively exposed to moxa smoke of 0%， 10%， 40%， 70% concentration (in terms of opacity) for 20 min each day ， after 26 weeks rats were executed and drawn materials and with ELISA method ox-LDL、vWF in rats blood serum of different group were tested. Results: vWF showed downtrend as the concentration of moxa smoke ascended， which of low， medium， high concenteation group significantly declined compared with control group; It has significantly rise in medium cencentrtion group compared with control group，the rest groups had no significant change by contrast with control group. Conclusion: 1) The rise of concentration of moxa smoke brings down Platelet aggregation，promotes body metabolism and improves microcirculation. 2) Low concentration of moxa smoke indicates no injury on vascular endothelial.