Acupoint has been regarded as both crucial and initiate step for generating clinic efficacy by moxibustion therapy.So the local acupoint would to be an important target to uncover the mechanism of moxibustion.This review mainly focus on discussing the biological mechanism of changed temperature，blood flow，molecular events，immunity，transient receptor potential，and purinergic signaling at the moxibustioned site caused by moxibustion stimulation.