To observe the effects of different moxibustion temperature on primary hyperlipidemia patients with serum Ox-LDL， component， ET-1， NO， ET-1/NO， and discuss moxibustion mechanism of promoting “tong” though “wen”. Methods: A taotal of 42 cases of primary hyperlipidemia were randomly divided into 45 ℃ group and 38 ℃ group， with 21 cases in each. The temperature of two groups was controled by adjusting the moxibustion distance and the frequency of moving moxibustion ash， and the thermometer accuratly monitor skin temperature. Each point for 10 minutes， once every other day， 6 weeks as 1 course of treatment， totally 2 courses (12 weeks)， elbow venous blood 10ml， detect blood fat and serum Ox-LDL， ET-1， NO. Results: 45 ℃ group have lipid-lowering effect， the effect is superior to that of TC， TG in 38 ℃ group(P<0.05)，the content of Ox-LDL， ET-1， ET-1/NO in serum of patients with hyperlipidemia in 45 ℃ group were decreased (P<0.001) after moxibustion. Regulation effect of 45 ℃ moxibustion on Ox-LDL， NO， ET-1/NO， was obviously better than 38 ℃. Conclusion: the role of 45 ℃ moxibustion stimulation in “tiao zhi tong mai” was better than 38 ℃， the temperature of moxibustion can effect clinical effect， the suitable temperature is the key factor of moxibustion stimulation effect， TRPV1 may mediate moxibustion mechanism in promoting “tong” effect by “wen”. Moxibustion sensation between burning and pain the is best moxibustion sensation.