Based on the research of principles and mechanism of warm-unblock and warm-tonic effects induced by moxibustion，one branch of the moxibustion project supported by the National Key Basic Research and Development Program (973 Program)，focused on the hypothesis that burning moxa could generate warm-unblock and warm-tonic effects by warm stimulation，taken epigastralgia with spleen yang deficiency syndrome as the target disease，followed its pathogenesis that middle Jiao fail to transportation due to the deficiency of spleen yang，considered the corresponding treatment principle of tonifying spleen and stomach by warm，unblock and tonification，the study aims to explore the mechanism of warm-unblock and warm-tonic effects，the relation between these two effects and the characteristics of effects rules.The preliminary results showed that the mechanism of warm-unblock and warm-tonic effects could be modulation the neural-endocrine-immune pathway and also the function of Zangfu organs，and promotion the circulation of Qi and blood by activating the related acupoints.They also indicated that the relations of effects would be presented as following：warm-effect would promote unblock-effect and generate tonic-effect; unblock-effect would enhance tonic-effect，and vice versa.Moreover，they pointed out the characteristics of effect principles might be unblock- and tonic-effect features，particularity，conditionality，extent，diversity and sustainability.