世界中医药

目的：观察复方亚甲蓝液局部封闭联合自拟中药汤剂熏洗治疗肛门瘙痒症(Peritus Ani，PA)的临床疗效。方法：将我院自2008年5月至2012年3月收治的90例肛门瘙痒症患者按照随机数字表法随机分为治疗组与对照组，各45例，2组患者均给予复方亚甲蓝液局部封闭治疗，治疗组加用自拟中药汤剂熏洗患处。2组患者治疗2周为1个疗程，比较临床疗效。结果：治疗组总有效率明显高于对照组(χ2=11.025，P<0.01)，具有统计学意义。2组患者各项症状评分比较无统计学意义(P>0.05)，治疗后2组患者症状均有明显改善(P<0.05)，但治疗组较对照组改善明显(P<0.01)，具有统计学意义。治疗组瘙痒消失时间、睡眠改善时间及皮损消失时间均较对照组明显缩短(P<0.01)，具有统计学意义。结论：复方亚甲蓝液局部封闭联合自拟中药汤剂熏洗治疗肛门瘙痒症疗效良好，可显著缩短患者临床症状、体征改善时间，提高治疗效果，值得推广应用。

English Summary:

To observe the therapeutic effect of methylene blue solution partially closed combined with Chinese medicine decoction fumigation for the treatment of anal pruritus. Methods:Ninety patients admitted to our hospital from May 2008 to March 2012 with anal pruritus according were randomly divided into treatment group and control group with 45 cases in each group. Patients in both groups were treated with the compound methylene blue solution partial closure， and treatment group gave patients extra Chinese medicine decoction fumigation and washing on the affected areas. The treatment courses of the two groups were both 2 weeks， and the clinical therapeutic effects were compared. Results:The total effective rate in treatment group was significantly higher than that in the control group (χ2=11.025，P<0.01)，with statistical significance. The symptom scores of the two groups of patients showed no significant difference (P>0.05). The time length of disappearance of pruitus， sleep improvement and vanishing of skin lesions were significantly shorter in treatment group (P<0.01). Conclusion: The methylene blue solution partially closed combined with Chinese medicine decoction fumigation for the treatment of anal pruritus shows satisfactory efficacy， it can significantly shorten the time of improving patient′s clinical symptoms and signs which worth generalizing.

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