To explore the clinical efficacy and safety of TCM treating generalized anxiety disorder. Methods: Ninety six patients with generalized anxiety disorder were selected in light of CCMD-3 diagnostic criteria. Patients were given TCM formulas of different syndrome patterns according to their syndrome differentiation for 6 weeks. Hamilton anxiety scale (HAMA) and Treatment Emergent Symptom Scale (TESS) were assessed before and after treatment in order to determine the efficacy and adverse reaction. Results: After the treatment， the total effective rate was 82.8%， and the total score of HAMA were significantly decreased (P<0.05). There was no obvious side reaction. Conclusion: TCM is effective in the treatment of general anxiety disorder with high safety， and it is worth generalizing.