To investigate the effect of the Bushenyixin decoction on the vascular endothelial dysfunction in spontaneously hypertensive rats (SHR). Methods: A total of 40 rats with spontaneously hypertension were randomly divided into the blank control group， large， medium， and small dose Bushenyixin decoction group， with 10 rats in each group and each group was fed with basic feed. The large， medium， small dose Bushenyixin decoction groups were fed with the BushenYixin Tang 15ml， 10ml， and 5ml addition to the basic feed daily. Blood nitric oxide (NO) and endothelin (ET) were measured before the experiment and on the 8th weekend after the start of the experiment. Results: The NO of the experiment groups was significantly increased after the experiment， and the blood pressure and ET level were significantly decreased. Changes in the large dose group was most significant. Conclusion: Bushenyixin decoction can significantly improve the NO level of vascular endothelial growth factor， reduce the level of ET in spontaneously hypertensive rats， so as to improve the function of vascular endothelium.