To observe the effects of wind-dispelling medicine， deficiency-nourishing medicine， wind-dispelling medicine assisted with deficiency-nourishing medicine of Houshiheisan on the expression of APP and Aβ42 in cerebral ischemic rats. Methods: Local cerebral ischemia injured rats was replicated by occlusion of the right middle cerebral artery. The immunohistochemistry and MIPS were used to measure the expressions of APP and Aβ42 in the cortex after cerebral ischemia. Results: Expressions of APP and Aβ42 were significantly increased in model group in comparison with sham group (P<0.01). Twenty-four hours after cerebral ischemic occurred， deficiency-nourishing medicine and combination group reduced expression of APP. There was a significant difference in comparison with model group (P<0.05). Forty-eight hours after cerebral ischemic occurred， wind-dispelling medicine reduced expression of APP. There was a statistically difference in comparison with model group (P<0.05). Forty-eight hours after cerebral ischemic occurred， combination group could reduce expressions of Aβ42. There was a significant difference in comparison with the model group (P<0.01). Conclusion: Wind-dispelling medicine assisted with deficiency-nourishing medicine of Houshiheisan can reduce the expression of APP， inhibition aggregation of Aβ42， and the cytoxicity of Aβ42， thus resisting the ischemia injure.