This article was intended to observe the clinical effect of hand therapy on San Yin Jiao (PC6) combined with moxibustion at the region of lower belly in the treatment of primary dysmenohhea. Methods: A total of 60 patients were randomized into two groups， the experimental group and the control group. In the experimental group， 30 patients with primary dysmenorrhea were treated by hand therapy of kneading and pressing at the point of San Yin Jiao (PC6) combined with moxibustion at the region of lower belly. Hand therapy procedure was carried out by the same acupuncturist with the tip of thumb targeting at tingling， numbing or pain at the acupoints which the patients could accept; while moxibustion was performed to each patient in 30 minutes， repeated one hour later， not more than three times altogether. Capsule of Fenbid was administered to those patients who showed no response to the therapies mentioned above and this therapy was also applied to the control group containing another 30 patients. Time limit of the observation was within three hours to each of the 60 objects in either group. Results: In the experimental group， 24 among 30 objects showed significant effect， 5 showed mild effect and one showed no effect; while in the control group， 21 showed significant effect， 6 showed mild effect and 3 showed no effect. Conclusion: The experimental hand therapy and moxibustion therapy， is effective in treating primary dysmenorrhea， and this non-drug therapy shows new promise in relieving pain that occurs in primary dysmenorrhea， at least in decreasing the dose of pain killing drugs in the experiment.