Take different oral hypoglycemic drugs to compose different therapeutic schemes， and compare the differences among these therapeutic schemes in terms of economics， efficacy and safety. Discuss the advantages of Xiaoke pill in pharmacoeconomic aspects. Methods: A total of 296 cases of patients with diabetes mellitus were randomly divided into four groups， and adopted four kinds of treatment.Observe the clinical efficacy and cost effectiveness of the four groups of patients. Results: The four therapeutic schemes had no significant difference in efficacy or safety. In the study of pharmaceutical economics， Metformin group had the lowest rate of C/E and total cost /HbA1c. Xiaoke pill group ranked second， followed by Glipizide group and Repaglinide group. Conclusion: Considering the efficacy， safety and economy aspects， metformin or Xiaoke pill can be used for initial therapy for type-2 diabetes. Combination of the two can also be used if necessary. Through effective management， it helps to save cost and improve the level of blood glucose control.