Observe the effect of Qiliqiangxin capsule in improving short-term heart function in chronic obstinate heart failure patients. Methods: A total of 58 cases of chronic heart failure patients who are resistant to conventional heart failure treatment were included. Patients were given Qiliqiangxin capsule， 4 pieces， 3 times/d， for 3 months. Left ventricular end-diastolic diameter (LVED)， left ventricular ejection fraction (EF)， C-reactie protein (CRP)， N end forebrain sodium element (NT-BNP)， PR interval， and change of QT period were observed before and after treatment. After treatment， LVED was narrowed， PR and QT interphase shortened， BNP dropped， and EF improved， with significant difference compared to before treatment (P< 0.01); the drop of CRP was statistical significant compared with before treatment (P< 0.05). Results: In terms of symptoms improvement， among 58 patients that participated the experiment， 32 cases received significant efficacy， 22 moderate， and four ineffective – the effective rate was 93.10%. Conclusion: Qiliqiangxin capsule has good therapeutic effect on chronic obstinate heart failure in the short term. Its mechanism is effective in improving endothelial function， reducing blood vessels inflammatory reaction， reasonable improving atrioventricular conduction， restraining ventricular remodeling and improving shrinkage function and so on.