世界中医药

目的:探讨补中益气汤对慢性阻塞性肺疾病(COPD)急性加重期患者肺功能的影响。方法:74例COPD急性加重期患者随机分为观察组(n=37)与对照组(n=37),对照组给予沐舒坦雾化吸入治疗,观察组在对照组基础上加用补中益气汤加味治疗,对比两组综合疗效及肺功能。结果:观察组显效率及有效率均显著高于对照组(P<0.05);治疗后观察组FEV1、FVC均显著高于治疗前(P<0.05或P<0.01),FEV1/FVC未见明显变化(P>0.05),对照组3项指标在治疗前后均无明显变化(P>0.05),且治疗后观察组FEV1、FVC均显著高于对照组(P<0.05);不良反应发生率无统计学意义(P>0.05)。结论:补中益气汤在急性加重期COPD患者中的应用,具有确切的综合临床疗效,同时对于患者肺功能的提高具有重要作用,且安全可靠,值得推广。

English Summary:

To discuss the influence of Buzhong Yiqi decoction on lung function in patients with acute exacerbation COPD.Methods:74 patients with acute exacerbation COPD were randomly divided into the observation group(n=37) and the control group(n=37),the control group were treated with ambroxol inhalation, the observation group were treated with Buzhong Yiqi decoction in addition to ambroxol inhalation. Comprehensive efficacy and the lung function were compared between the two groups. Results: The significant efficacy and the overall efficacy of the observation group were significantly higher than the control group(P<0.05);FEV1 and FVC in the observation group were significantly improved after the treatment(P<0.05 or P<0.01),but no significant improvement of FEV1/FVC(P>0.05), or three lung function indicators were observed after treatment (P>0.05),but FEV1 and FVC in the observation group were significantly higher than the control group after the treatment(P<0.05),no significantly difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Buzhong Yiqi decoction has definite treatment effects in patients with acute exacerbation COPD,and can effectively improve patients' lung function, its efficacy and safety is recommendable for clinical application..

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