| 引用本文:刘 彬1 关小红1 王小辉1 李钰瑶2.皮炎康颗粒对小鼠慢性变应性接触性皮炎的实验研究[J].世界中医药,2013,8(09):. |
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| 皮炎康颗粒对小鼠慢性变应性接触性皮炎的实验研究 |
| Study on Piyankang Granules Treating Mice with Chronic Allergic Contact Dermatitis |
| 投稿时间：2013-01-09 |
| DOI：10.3969/j.issn.1673-7202.2013.09.030 |
| 中文关键词: 皮炎康颗粒 胸腺指数 脾指数 |
| English Keywords:Piyankang Granules Thymus index Spleen index |
| 基金项目:沈阳市科技局专项资金资助项目(编号:F10-149-9-13) |
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| 中文摘要: |
| 目的:探讨皮炎康颗粒对小鼠慢性变应性接触性皮炎耳肿胀度、胸腺指数、脾指数的影响。方法:采用2,4-二硝基氯苯(DNCB)建立小鼠慢性变应性接触性皮炎(Allergic Contact Dermatitis,ACD)模型,设定皮炎康颗粒高(4倍等效量)、中(2倍等效量)、低(等效量)3个剂量组和氯雷他定片高剂量(4倍量)组、空白组、模型组。观察皮炎康颗粒对慢性ACD小鼠左、右耳重量差、耳厚度差,胸腺指数、脾指数的影响。结果:模型组与空白组相比耳重量差、耳厚度差均明显增加,与空白组相比,有统计学意义(P<0.01)。皮炎康颗粒各剂量组和氯雷他定片组均能减轻小鼠耳重量差、耳厚度差,与模型组相比,有统计学意义(P<0.01或P<0.05)；模型组与空白组相比胸腺指数、脾指数均明显增加,与空白组相比,有统计学意义(P<0.01)。皮炎康各剂量组和氯雷他定片组均能降低小鼠胸腺指数、脾指数,与模型组相比,有统计学意义(P<0.01或P<0.05)。结论:皮炎康颗粒可明显改善DNCB引起的慢性变应性接触性皮炎模型小鼠的耳部肿胀,具有一定的抗炎作用,并能降低胸腺指数及脾指数。 |
| English Summary: |
| To discuss the influence of Piyankang Granules on ear swelling, thymus index and spleen index of mice with allergic contact dermatitis (ACD). Methods: The mice ACD model was established with DNCB. There were Piyankang granules high dose group, middle dose group and low dose group, as well as Lomtadine high dose group, blank group and model group. The influence on weight difference of left and right ears, ear thickness, thymus index and spleen index were observed. Results: Compared with blank group, ear weight, ear thickness of mice in the model group were significantly increased, and there were significant differences between the two groups (P<0.05); Piyankang granules in each dosage group and Lomtadine high dose group all showed reduction in ear weight, ear thickness, and there all were significant differences compared with the model group (P<0.01 or P<0.05); compared with blank group, the thymus index and the spleen index of the mice in the model group were significantly increased, and there were significant differences between the two groups(P<0.01); reduction of the thymus index and the spleen index were seen in Piyankang granules of each dosage group and Lomtadine high dose group, and there were all significant differences compared with the blank group (P<0.01 or P<0.05). Conclusion: Piyankang Granules can obviously improve the ear swelling of mice with DNCE-induced ACD and has anti-inflammation effect. It also can reduce the thymus index as well as the spleen index. |
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