| 引用本文:李冬梅 徐 丽 曹军平 闫赋琴.七叶皂苷钠预防术后肠粘连的实验和临床研究[J].世界中医药,2013,8(10):. |
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| 七叶皂苷钠预防术后肠粘连的实验和临床研究 |
| Experimental and Clinical Studies on Sodium Aescinate in Preventing Postoperative Intestinal Adhesion |
| 投稿时间：2013-01-25 |
| DOI：10.3969/j.issn.1673-7202.2013.10.012 |
| 中文关键词: 七叶皂苷钠 肠粘连 预防作用 |
| English Keywords:Sodium aescinate Intestinal adhesion Prevention |
| 基金项目: |
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| 中文摘要: |
| 目的:研究七叶皂苷钠对术后肠粘连的防治效果。方法:SD大鼠制备术后肠粘连模型，分为假手术组、模型组、阳性组(地塞米松5 mg/kg)、给药组(七叶皂苷钠2 mg/kg)，均采用尾静脉注射给药，术前给药1次，术后继续给药3 d，术后1周各组进行粘连程度分级并观察组织病理变化。在动物实验的基础上，抽取腹部手术患者80例，分为给药组和对照组，观察静脉滴注七叶皂苷钠对肠粘连的防治效果。结果:七叶皂苷钠明显减轻大鼠术后肠粘连的分级程度(P<0.05)，缓解粘连组织的炎性渗出和炎症反应;可使患者术后腹痛腹胀、排便排气停止、肠梗阻的发生率明显降低(P<0.05)。结论:七叶皂苷钠能够预防腹腔术后肠粘连的形成。 |
| English Summary: |
| To study the preventive and curative effect of sodium aescinate (SA) on postoperative intestinal adhesion. Methods: SD rats were subjected to operation for establishing intestinal adhesion models, then they were randomly divided into 4 groups (n=10), namely normal group, model group, positive group (given Dexamethasone, i.v. 5 mg/kg) and SA group (i.v.2 mg/kg). Drugs were given one time before operation and continuous 3 days after operation. Seven days after operation, all of rats were killed, and the intestinal adhesion was graded and the tissues were observed through optical microscope. Based on the experimental study, 80 patients after abdominal surgeries were divided into drug group and control group so as to observe the clinical therapeutic effect of SA (i.v.). Results: SA evidently reduced the severity of postoperative adhesion in rats (P<0.05), and relieved the tissue inflammation. Clinical observation showed that the symptoms, abdominal pain and distension, flatus-defecation, intestinal obstruction, were much better relieved in the drug group treated with SA than those in the control group (P<0.05). Conclusion: SA could inhibit the formation of postoperative intestinal adhesion effectively. |
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