To observe the clinical curative effect of eyesight rehabilitation decoction combined with traditional Chinese medicine acupoint application in treatment of patients with optic atrophy. Methods:A total of 74 cases patients (108 eye) were divided into observation group and against group according to random digital table: observation group 38 cases (52 eye), control group 36 cases (56 eye). Observation group received oral eyesight recovery decoction and Chinese medicine ointment treatment on the temple that is on the same side with the diseased eye. Control group used troxerutin, muscle glycoside, cobamamide, citicoline, and vitamin B1 treatment. Results: A total of 9 patients in the observation group showed significant improvements, demonstrating 17.31% efficiency, total effective rate being 75.00 %. Control group had effects on 3 eyes, demonstrating 5.36 % efficiency, total effective rate being 60.71%. In the observation group, 8 cases showed improvements on vision defects, demonstrating 15.38 % efficiency, with total effective rate being 78.85 %. Control group had improvements on 2 eyes, showing 3.58 % efficiency, with total effective rate being 58.93 %. In the observation group, F-VEP P100 wave incubation period was effective on 8 eyes, 15.38% efficiency, with total effective rate being 76.92 %. Control group had an effect on 3 eyes, 5.36 % efficiency, with total effective rate being 58.93 %. The two groups showed no significant difference in terms of eyesight, vision defect and F-VEP P100 wave incubation period (P>0.05), while differences of efficacy was significant (P<0.05). Conclusion: Eyesight recovery decoction combined with TCM acupoint application is effective in improving vision in patients with optic nerve atrophy. It generally reduces field of vision defects, and shorten F-VEP P100 wave incubation period.