| 引用本文:林 凡1 刘林梅2 练祝明2 刘如玉1 吴世代1.血府逐瘀汤对人脐静脉内皮细胞一氧化氮适度刺激作用的研究[J].世界中医药,2013,8(11):. |
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| 血府逐瘀汤对人脐静脉内皮细胞一氧化氮适度刺激作用的研究 |
| Study on Moderate Stimulation Function of Xuefu Zhuyu Decoction on Levels of Nitric Oxide Released from Human Umbilical Vein Endothelial Cells |
| 投稿时间：2013-03-12 |
| DOI：10.3969/j.issn.1673-7202.2013.11.023 |
| 中文关键词: 血府逐瘀汤 人内皮细胞 一氧化氮 适度刺激 |
| English Keywords:Xuefu Zhuyu Decoction Endothelial cell Nitric oxide Moderate stimulation |
| 基金项目:国家自然科学基金项目(编号：81102844);福建省自然科学基金项目(编号：2010J05070);福建省教育厅资助项目(编号：JA11134);福建中医药大学校管项目(编号：X2009064 |
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| 中文摘要: |
| 目的：探讨血府逐瘀汤对人脐静脉内皮细胞一氧化氮(Nitric oxide，NO)产生的影响。方法：以人脐静脉内皮细胞(Human Umbilical Vein Endothelial Cell-12，HUVEC-12)为材料，采用不同血府逐瘀汤含药血清浓度和干预时间处理HUVEC-12，检测细胞培养上清液中NO浓度的变化。结果：与空白对照组对比，血府逐瘀汤可在一定干预时间段，适度诱导HUVEC-12胞外NO的产生(P<0.05)。结论：血府逐瘀汤可能通过适度刺激人内皮细胞NO产生，发挥促进血管新生作用，又避免增生过度的不良反应。 |
| English Summary: |
| To investigate effects of Xuefu Zhuyu Decoction(XFZYD) on levels of Nitric oxide (NO) released from Human Umbilical Vein Endothelial cells. Methods: Endothelial cells HUVEC-12 were incubated with blank serum or XFZYD containing serum (XFZYD-CS) at different concentrations and different times. Thereafter, the NO concentrations in the culture supernatant liquid were determined. Results: Compared with the control group, XFZYD-CS has a moderate stimulatory effect on NO production of this endothelial cell line in a period of time. Conclusion: Xuefu Zhuyu Decoction moderately increases the endothelial NO concentration to promote angiogenesis without causing overgrown blood vessels. |
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