世界中医药

作者	单位
王佟1 高铸烨2 焦阳3 韩文忠1 郭华1 郭晓平1	1 河北省沧州市中西医结合医院心内科，沧州，061000； 2 中国中医科学院心血管病研究所，北京，100091； 3 北京中医药大学，北京，100029

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中文摘要:

目的：调查分析沧州中西医结合医院冠心病住院患者的联合用药状况。方法：采用临床流行病学横断面调查方法，利用医院信息系统(Hospital Information System，HIS)提取冠心病住院患者的一般临床资料及诊断用药数据，采用SPSS13.0软件对联合用药情况进行描述性分析。结果：643例冠心病患者符合入选标准，其中心绞痛308例(占47.90%)、心力衰竭238例(占37.01%)、急性心肌梗死97例(占15.09%)。年龄29~91岁，平均(64.39±12.44)岁；男性417例（64.85%），女性226例（35.15%）。患者住院天数1~48 d，平均住院(12.15±5.82)d。主要并存疾病是糖尿病、高血压、高脂血症、呼吸系统疾病、脑血管疾病、慢性肾功能不全，以4~6种疾病共存为多见。共计应用西药2~33类，77种，平均（7.54±3.83）类，（16.38±7.31）种。513例（79.78%）患者使用了中成药，总计79种，单个患者使用3~18种，平均使用（10.68±4.21）种。376例（58.48%）患者服用了中药汤剂，中药汤剂药味4~50味，平均(16.18±6.37)味；联合用药（包括中药、中成药、西药）数2~60种，平均用药(18.49±9.24)种，77%以上的患者使用了5~26种药物。结论：冠心病常多种疾病并存，联合用药是治疗冠心病的常用策略，药物联合应用的交互作用、临床疗效和安全性有待进一步研究。

English Summary:

To analyze combined treatment status of hospitalized patients with coronary heart disease (CHD) admitted in Cangzhou Integrative Medicine Hospital. Methods：Cross-sectional study methods of clinical epidemiology were conducted. The Hospital Information System（HIS) was used to extract general clinical data and diagnostic drug data of hospitalized patients with CHD. SPSS13.0 software was used to analyze drug combination. Results：There were altogether 643 cases meeting the inclusion criteria，among which 308 cases were angina pectoris(accounting for 47.90%)，238 cases were heart failure ( accounting for 37.01% ) and 97 cases were acute myocardial infarction ( accounting for 15.09% ). The patients’ ages ranged from 29 to 91 years old，with an average age of （64.39 ± 12.44） years old. There were 417 male cases (64.85%) and 226 female cases (35.15%). Patients were in hospital for 1 to 48 days with an average of （12.15 ± 5.82） days. Major comorbidities were diabetes，hypertension，hyperlipidemia，disease of respiratory system，cerebrovascular disease and chronic renal insufficiency，and patients were usually with 4 to 6 diseases. Western medicine applied were 2 to 33 categories with 77 kinds，averagely （7.54 ± 3.83） categories and （16.38 ± 7.31） kinds. There were 513 (79.78%) patients used 79 kinds of Chinese patent medicine，averagely （10.68 ± 4.21） kinds. Altogether 376 cases (58.48%) patients took the decoction，and the herbal medicines in a prescription were 4-50 species，averagely （16.18 ± 6.37） species. Integrated western and Chinese medicine (including traditional Chinese medicine，Chinese patent drug and western medicine) used were 2 to 60 categories，with an average of （18.49 ± 9.24） categories. 77% of patients used 5 to 26 pharmaceutical composition. Conclusion：The multiple diseases coexisted with CHD. Integrated Chinese and Western medicine was commonly used for treatment strategies of CHD. Interactions，clinical efficacy and safety among medications need further study.

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