| 引用本文:刘晨旭1 潘龙毅1 周 斌2.中药制剂艾迪注射液联合顺铂治疗肺癌胸水的疗效观察[J].世界中医药,2013,8(12):. |
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| 中药制剂艾迪注射液联合顺铂治疗肺癌胸水的疗效观察 |
| The Curative Effect of Addie Injection of Traditional Chinese Medicine combined with Cisplatin on the Treatment of Lung Cancer with Hydrothorax |
| 投稿时间：2013-06-25 |
| DOI：10.3969/j.issn.1673-7202.2013.12.014 |
| 中文关键词: 肺癌 顺铂 胸腔积液 艾迪注射液 |
| English Keywords:Lung Cancer Cisplatin Addie Injection Hydrothorax |
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| 中文摘要: |
| 目的：探讨顺铂化疗联合中药制剂艾迪注射液治疗肺癌胸水的疗效。方法：将112例肺癌胸腔积水患者随机分为对照组和治疗组，每组均为56例。对照组每周胸腔内注入顺铂25 mg/m2，治疗组在对照组基础上每周胸腔内注入中药制剂艾迪注射液70 mL，治疗4周后，观察和比较两组的临床疗效，T细胞亚群水平变化，不良反应和KPS质量评分。结果：治疗组总有效率达到67.86%，显著高于对照组46.42%(P<0.05);治疗组治疗后CD3+、CD4+和CD4+/CD8+水平与治疗前差异无统计学意义(P>0.05)，且显著高于对照组水平(P<0.05);治疗组治疗后KPS平均评分为(73.90±6.46)分，显著高于对照组(67.25±6.52)分和治疗前水(P<0.05);总不良反应率为33.93%，显著低于对照组66.07%(P<0.05)。结论：中药制剂艾迪注射液联合顺铂治疗肺癌胸腔积水，能显著改善患者免疫功能，提高患者治疗后生活质量，且不良反应轻，综合疗效优于单独采用顺铂治疗。 |
| English Summary: |
| To study the curative effect of Addie injection of traditional Chinese medicine combined with cisplatin on patients with lung cancer and hydrothorax. Methods：A total number of 112 patients of lung cancer with hydrothorax were randomly divided into the control group and the observation group，with 56 cases in each group. The control group gave patients intra-pleural injection of 25 mg/m2 of cisplatin weekly while the observation group weekly applied intra-pleural injection of 70 mL of traditional Chinese medicine Addie except from the same medicine of the control group. The clinical effects，the changes of T cell subsets，the toxicity and KPS quality score between two groups after the treatment were compared after 4 weeks of treatment. Results：The total effective rate in the observation group reached to 67.86%，which was significantly higher than that of the control group 46.42% (P<0.05); After treatment，the CD3+，CD4+ and CD4+/ CD8+ levels in the observation had no significant difference compared with those before treatment (P>0.05)，however significantly higher than those of the control group after treatment (P<0.05); KPS average score of the observation group after treatment was (73.90 ± 6.46)，which was significantly higher than that of the control group (67.25 ± 6.52) and before treatment (P<0.05); the total side effect rate of the observation group was 33.93%，significantly lower than that of the control group 66.07% (P<0.05).Conclusion：Addie injection of traditional Chinese medicine combined with cisplatin could significantly improve the immune function of patients，improve the quality of life of patients after treatment with slight side effects，which shows that the comprehensive curative effect is better than the single application of cisplatin treatment. |
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