| 引用本文:柯敏辉1 叶 玲1 陈立武1 吴华嵩2 魏 霖1 郑鸣霄1.兔直肠黏膜内脱垂模型的建立[J].世界中医药,2013,8(12):. |
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| 兔直肠黏膜内脱垂模型的建立 |
| The Animal Model of Internal Rectal Prolapse in Rabbits |
| 投稿时间：2013-06-17 |
| DOI：10.3969/j.issn.1673-7202.2013.12.025 |
| 中文关键词: 直肠黏膜内脱垂 兔 动物模型 |
| English Keywords:Internal rectal prolapse Rabbit Animal Model |
| 基金项目:国家自然基金(编号：81173272);福建省中医临床研究基地重点专科(专病)项目(编号：zlcgc04) |
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| 中文摘要: |
| 目的：研制IRP兔模型。方法：取新西兰兔30只，随机分成正常组与造模组。造模组采用大黄和番泻叶灌胃、无水乙醇肛周注射与站立三种方法联合造IRP兔模型。比较正常组与造模组肛镜下直肠黏膜脱垂情况及直肠壁显微结构情况。结果：与正常组相比，造模组直肠黏膜内脱垂明显，直肠壁病理征象符合IRP的标准。结论：复合方法造IRP兔模型，方法可靠。 |
| English Summary: |
| To develop IRP rabbit model. Methods： Thirty New Zealand rabbits were randomly divided into normal group and model group. Three methods were conducted to make the rabbit models. The three methods contain rhubarb and senna gavage，perianal injection of anhydrous alcohol and stand. The prolapse of rectal mucosa under the anus mirror and the microscopic structure of rectum between the normal group and the model group were compared. Results： Compared with the normal group，internal rectal prolapse were significantly different in the model group. Pathological findings were in accordance with IRP standards. Conclusion： Composite method of IRP rabbit model is reliable. |
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