| 引用本文:范 亚 丽.中西医结合治疗甲状腺功能亢进症近期疗效及远期复发率观察[J].世界中医药,2014,9(02):. |
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| 中西医结合治疗甲状腺功能亢进症近期疗效及远期复发率观察 |
| Therapeutic Efficacy of Combined Treatment of Traditional Chinese and Western Medicine on Hyperthyroidism and Long-term Recurrence |
| 投稿时间：2013-06-19 |
| DOI：10.3969/j.issn.1673-7202.2014.02.017 |
| 中文关键词: 甲状腺功能亢进症 辨证论治 甲巯咪唑 中西医结合疗法 |
| English Keywords:Hyperthyroidism Syndrome differentiation and treatment Methyl mercaptoacetate imidazole Combined therapy of Chinese and Western medicine |
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| 中文摘要: |
| 目的：观察中西医结合治疗甲状腺功能亢进症的近期疗效和远期复发率。方法：将符合标准的74例患者随机分为两组，对照组40例采用甲巯咪唑治疗，治疗组34例在对照组基础上加用中药辨证论治，肝郁气滞化火者用柴胡疏肝散加减，阴虚火旺、痰瘀凝结者用知柏地黄丸合消瘰丸加减，气阴两虚兼痰瘀互结者予以生脉散、二至丸合消瘰丸加减。观察患者临床症状、体征和甲状腺功能变化情况、不良反应发生情况和复发率。结果：治疗组临床痊愈率和总有效率分别为44.12%、88.24%，对照组临床痊愈率和总有效率分别为25.00%、77.50%。两组比较，差异有统计学意义(P<0.05)。治疗1个月后，治疗组症状总积分低于对照组，但差异无统计学意义;自治疗3个月起，组间比较，差异均有统计学意义(P<0.05)。治疗后两组TT3、TT4、FT3、FT4和TRAb均降低，TSH升高，组间比较，差异均有统计学意义(P<0.05)。治疗组和对照组不良反应率分别为5.88%、15.00%，差异有统计学意义(P<0.05)，以肝功能损害最为常见。临床痊愈患者中，治疗组复发6例，复发率40.00%，对照组复发6例，复发率60.00%。结论：甲巯咪唑联合中药辨证论治用于甲状腺功能亢进症，可有效改善患者临床症状和甲状腺功能，降低药物不良反应发生率，减少复发。 |
| English Summary: |
| To observe therapeutic efficacy of combined treatment of traditional Chinese and western medicine on hyperthyroidism and long-term recurrence.Methods：Seventy four patients were randomly divided into two groups， control group (40 cases) used Methyl mercaptoacetate imidazole， observation group (34 cases) used Methyl mercaptoacetate imidazole plus Chinese medicine treatment based on syndrome differentiation：liver stagnation resulting in exuberating fire used modified bupleurum Powder， Yin-deficiency， fire-exuberant phlegm-stagnation used modified Zhibai Dihang Pill and Xiaoluo Pill， qi- yin deficiency， phlegm stagnation used modified Shengmai Powder， Erzhi Pill and Xiaoluo Pill.After treatment， we compared changes of thyroid function， symptoms， physical signs， adverse reaction and recurrence.Results：Clinical cure rates and total effective rate of observation group were respectively， 44.12% and 88.24%， those of the control group were 25.00% and 77.50% (P<0.05).After 1-month treatment， the observer group’s total symptom score was lower than the control group (P>0.05)， the difference showed statistic significance after 3-months treatment (P<0.05).After treatment TT3、TT4、FT3、FT4and TRAb were reduced and TSH elevated in both groups with significant difference between the groups (P<0.05).AE occurrence rates of observation group and control group were respectively， 5.88% and 15.00% (P<0.05)， liver damage was most noticeable.The observer group had 6 reoccurrences， recurrence rate =40%， the control group had 6 cases， recurrence rate = 60%.Conclusion：Thiamazole combined with traditional Chinese medicine can effectively treat clinical symptoms and thyroid function of hyperthyroidism， control adverse reaction and recurrence. |
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