| 引用本文:于兴兵 张贤春 谢振年.地龙提取液治疗糖尿病足的疗效观察[J].世界中医药,2014,9(02):. |
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| 地龙提取液治疗糖尿病足的疗效观察 |
| Observation on Curative Effect of Earthworm Extract in Treating Diabetic Foot |
| 投稿时间：2013-06-05 |
| DOI：10.3969/j.issn.1673-7202.2014.02.018 |
| 中文关键词: 地龙 糖尿病足 中医药疗法 临床研究 |
| English Keywords:Earthworm Diabetic foot Chinese medical therapy Clinical study |
| 基金项目: |
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| 中文摘要: |
| 目的：观察地龙提取液治疗糖尿病足的临床疗效。方法：将符合标准的92例患者按随机数字表法分为治疗组(40例)和对照组(52例)。两组均采用常规西医处理，治疗组加用地龙提取液治疗。观察患者创面愈合情况、临床症状和C反应蛋白(CRP)、胰岛素样生长因子-1(IGF-1)、血管内皮细胞生长因子(VEGF)变化情况，以及不良反应发生情况。结果：治疗组和对照组总有效率分别为90.00%、82.69%，组间比较，差异有统计学意义(P<0.05)。两组患者治疗后组间比较，溃疡面积、脓性分泌物和创面肉芽组织的差异均有统计学意义(P<0.05)。治疗组创面愈合时间快于对照组，差异有统计学意义(P<0.05)。治疗后治疗组CRP低于对照组，IGF-1高于对照组，组间比较，差异均有统计学意义(P<0.05)。治疗第7 d起，治疗组患者血清VEGF高于对照组，各时间点组间比较，差异有统计学意义(P<0.05)。两组患者治疗过程中均未见明显不良反应。结论：地龙提取液联合常规西医对糖尿病足的临床疗效安全可靠，在改善患者溃疡面积、脓性分泌物和创面肉芽组织、加速创面愈合等方面均优于单纯西医治疗，其机制可能与降低CRP、提升IGF-1和VEGF水平有关。 |
| English Summary: |
| To observe clinical effect of earthworm extract in treating diabetic foot.Methods：Ninety two patients meeting the conclusion criteria were divided into treatment group (n=40) and control group (n=52) according to a random number table. Two groups both applied conventional western medicine, while treatment group gave patients extra application of earthworm extracts. Wound healing condition, clinical symptoms improvement, serum c-reactive protein (CRP), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF), and adverse events were observed.Results：The total effective rates of the treatment group and the control group were respectively 90% and 82.69%, which showed a statistically significant difference (P<0.05).The changes of the ulcer area, purulent secretions, and granulation tissue before and after treatment in both groups showed statistically significant differences (P<0.05).The time of wound healing in treatment group was faster than that of the control group, which showed a statistically significant difference (P<0.05). After treatment, CRP of patients in the treatment group were lower than that of the control group, and IGF-1 was higher in the treatment group, showing statistically significant differences between the groups (P<0.05). From the seventh day of the treatment, serum VEGF of the patients in treatment group was higher than that of the control group, and there were statistically significant differences between the two groups in different time (P<0.05). There were no adverse reactions occurred in both groups.Conclusion：Earthworm extracts combined with routine western medicine treating diabetic foot shows safe and reliable therapeutic effects, and it is better than the single usage of western medicine in terms of improving the ulcer area, purulent secretions, and granulation tissue, accelerating wound healing. Its mechanism may be related to lowering CRP, upgrading the level of IGF-1 and VEGF. |
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