| 引用本文:宋业琳 卢 娜 徐伟俊 魏陵博 于广宇 聂颖颖 迟伟峰 李 洁.补肾活血法对单纯收缩期高血压大鼠NO、AngⅡ的影响[J].世界中医药,2014,9(02):. |
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| 补肾活血法对单纯收缩期高血压大鼠NO、AngⅡ的影响 |
| Effect of Bushen Huoxue Method on Expression of NO and Ang Ⅱin Isolated Systolic Hypertension Rats |
| 投稿时间：2013-06-19 |
| DOI：10.3969/j.issn.1673-7202.2014.02.024 |
| 中文关键词: 补肾活血法 单纯收缩期高血压 一氧化氮 血管紧张素Ⅱ 血管顺应性 |
| English Keywords:Bushen Huoxue method Isolated systolic hypertension Nitric oxide Angiotensin Ⅱ Vascular compliance |
| 基金项目:2010年度青岛市公共领域科技支撑计划(编号：10-3-3-5-3-nsh) |
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| 中文摘要: |
| 目的：探讨补肾活血法对单纯收缩期高血压(Isolated Systolic Hypertension，ISH)模型大鼠血管重塑的影响。方法：采用法华林和维生素K诱导动脉中层钙化法(WVK)法复制ISH大鼠模型，分为补肾活血汤组、氨氯地平组、补肾活血汤与氨氯地平联用组(两药联用组)、空白对照组、模型对照组，予以相应的药物干预，8周后检测大鼠尾端血压、血清一氧化氮(Nitrogen Monoxide，NO)、血管紧张素Ⅱ(Angiotensin Ⅱ，AngⅡ)水平。结果：补肾活血法能够增加ISH大鼠血清NO水平，降低AngⅡ水平，较模型组均有统计学意义(P<0.05)，且中西药联用组效果更明显。结论：补肾活血法等够改善ISH大鼠的血管顺应性。 |
| English Summary: |
| To explore effect of the Bushen Huoxue method on vascular remodeling of isolated systolic hypertension (ISH) rats.Methods：ISH rats model was established by WVK method， divided into Bushen Huoxue decoction group， amlodipine group， Bushen Huoxue decoction- amlodipine combination group， blank control group， and model control group， gave corresponding drug intervention， measured rat’s tail blood pressure， serum NO level， AngⅡlevel after 8- week treatment.Results：Bushen Huoxue decoction can significantly increase serum NO level and reduce the AngⅡ level in ISH rats compared with model group (P<0.05).The Chinese and western medicine combination group was more effective.Conclusion：Bushen Huoxue method can improve vascular compliance in rats of isolated systolic hypertension. |
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