| 引用本文:徐 宁 唐海沁 张亚文.芪苈强心胶囊治疗慢性心力衰竭疗效分析[J].世界中医药,2014,9(02):. |
|
| 芪苈强心胶囊治疗慢性心力衰竭疗效分析 |
| A Systematic Review on The Effects of Qili Qiangxin Capsule Treating Chronic Heart Failure |
| 投稿时间：2013-12-20 |
| DOI：10.3969/j.issn.1673-7202.2014.02.031 |
| 中文关键词: 芪苈强心胶囊 慢性心力衰竭 Meta分析 |
| English Keywords:Exercise-based cardiac rehabilitation Coronary heart disease Chronic heart failure Meta-analysis |
| 基金项目:安徽省卫生厅基层慢病防治科技项目(编号：20140831) |
|
| 摘要点击次数: 1828 |
| 全文下载次数: 1819 |
| 中文摘要: |
| 目的：系统评价芪苈强心胶囊治疗慢性心力衰竭的有效性和安全性。方法：计算机检索2008年至2013年9月Cochrane图书馆临床对照试验资料库、Embase、Pubmed、中国学术期刊全文数据库、中国生物医学文献数据库、万方数据库、维普数据库,收集芪苈强心胶囊治疗慢性心力衰竭的试验，按纳入和排除标准共纳入28项研究2 536例患者，使用RevMan 5.0软件进行Meta分析。结果：芪苈强心胶囊可改善慢性心力衰竭患者的预后：1)降低NTpro-BNP及BNP：治疗组NTpro-BNP低于对照组［SMD=-1.57,95%CI(-1.79,-1.34)，P<0.000 01］,治疗组BNP低于对照组［SMD=-0.60,95%CI(-0.77,-0.43),P<0.000 01］；2)治疗组改善NYHA心功能分级效果好于对照组［OR=3.48.95% CI(2.66，4.55)，P<0.000 01］；3)治疗组6分钟步行试验距离远于对照组［SMD=1.03,95%CI(0.91,1.16),P<0.000 01］；4)治疗组左室射血分数明显高于对照组［SMD=1.06,95%CI(0.96,1.16),P<0.000 01］；5)治疗组不良反应发生率低于对照组［OR=0.23.95% CI(0.11，0.47)，P<0.000 01］。结论：根据目前研究结果，芪苈强心胶囊对改善慢性心力衰竭患者的心功能和生活质量是安全有效的。 |
| English Summary: |
| To systematically review the effects of Qili Qiangxin capsule treating chronic heart failure.Methods：Clinical trials on Qili Qiangxin capsules treating chronic heart failure(CHF) published during 2008 and September 2013 were searched from the following electronic databases including Cochrane Library, Embase, PubMed, CNKI, CBM, Wanfang, VIP. Altogether 28 studies including 2536 patients were included in the review, and the data were analyzed by using Review Manager 5.0.Results：Qili Qiangxin capsule can improve the prognosis of chronic heart failure. Meta-analysis results showed that, 1) Reducing the levels of N-terminal Pro of Pro-brain natriuretic peptide (NT-pro BNP) and brain natriuretic peptide(BNP)：the level of NT-pro BNP of the treatment group was lower than that of the control group ［SMD=-1.57,95%CI(-1.79,-1.34),P<0. 000 01］,the level of BNP in treatment was lower than that of the control group ［SMD=-0.60,95%CI(-0.77,-0.43),P<0.000 01］; 2) Treatment group better improved cardiac function NYHA ［OR=3.48．95% CI(2.66，4.55)，P<0.000 01］;3) The distance of 6-minute walking test was longer in treatment group ［SMD=1.03,95%CI(0.91,1.16),P<0.000 01］;4) Treatment group better improved the left ventricular ejection fraction ［SMD=1.06,95%CI(0.96,1.16),P<0.000 01］; 5) The incidence of adverse reactions was lower in treatment group ［OR=0.23．95% CI(0.11，0.47)，P<0.000 01］.Conclusion：Qili Qiangxin Capsule can obviously improve the cardiac function and the quality of life of patients with chronic heart failure, and it is safe and effective. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
