| 引用本文:孔令博1 刘清泉2 杨 琦1 高 洁3 付跃峰1.芪归银方对抗生素体外抑制多重耐药铜绿假单胞菌作用的影响[J].世界中医药,2014,9(03):. |
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| 芪归银方对抗生素体外抑制多重耐药铜绿假单胞菌作用的影响 |
| Study on the Effect of Qiguiyin Decoction and Antibiotics Inhibiting Multi-drug Resistant Pseudomonas Aeruginosa in Vitro |
| 投稿时间：2014-02-17 |
| DOI：10.3969/j.issn.1673-7202.2014.03.007 |
| 中文关键词: 芪归银方 含药血清 抗生素 多重耐药铜绿假单胞菌 体外抑菌 |
| English Keywords:Qiguiyin decoction Qiguiyin decoction-containing serum Antibiotics Multi-drug resistant Pseudomonas aeruginosa Bacteriostasis in vitro |
| 基金项目:国家“十一五”科技重大专项（编号：2009ZX09103-415）；国家“十二五”科技重大专项（编号：2013ZX09102026）；中医药行业科研专项（编号：200907001） |
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| 中文摘要: |
| 目的：探讨芪归银方含药血清联合抗生素对多重耐药铜绿假单胞菌的体外抑制作用。方法：运用二倍稀释法检测单用抗生素、空白血清、含药血清及血清联合抗生素的体外抑菌情况。结果：空白血清对多重耐药铜绿假单胞菌无体外抑菌作用，含药血清则具有明显的体外抑菌作用；抗生素联合含药血清较单纯抗生素和抗生素联合空白血清的抑菌情况有明显差异。结论：芪归银方含药血清能够降低抗生素的MIC值、MBC值，提高抑菌率，含药血清与抗生素具有体外协同抑菌作用。 |
| English Summary: |
| To explore the bacteriostasis effect of Qiguiyin decoction combined with antibiotics inhibiting multi-drug resistant pseudomonas aeruginosa in vitro. Methods： The antibacterial situation of antibiotics, blank serum, Qiguiyin decoction–containing serum and Qiguiyin decoction & antibiotics-containing serum in vitro were detected with double dilution method. Results： Blank serum had no effect of bacteriostasis on multi-drug resistant PA, while Qiguiyin decoction-containing serum had significant effect of bacteriostasis on it, and there was significant difference between them. Besides, the serum with both Qiguiyin decoction and antibiotics showed more significant bacteriostasis effect. Conclusion： Qiguiyin decoction-containing serum could reduce the content of MIC, MBC in antibiotics and increase the bacteriostasis rate. Qiguiyin Decoction-containing serum and antibiotics have significant cooperation effect of bacteriostasis on PA in vitro. |
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