To assess clinical effectiveness and adverse effect of integrated application of TCM in treating Rheumatoid Arthritis（RA）of retention of dampness-heat in channel type. Methods： A total amount of 60 RA patients admitted in our hospital from December 2010 to December 2012 were divided into observation group and control group according to a double-blind randomized controlled trial design method, with 30 cases in each group. Patients in the observation group were treated with Tripterygium Wilfordii and Wangbi granule, while control group applied oral hulisan capsule and compound fengshining. Comparison was made in terms of the clinical therapeutic effect after 4 weeks and 8 weeks of treatment, the time of morning stiffness, joint pain index, swelling index, rheumatoid factor negative and adverse reaction before and after treatment. Results： After 4 and 8 weeks of treatment, the total effective rates of the observation group were 83.3% and 90%, and those of the control group were 80% and 86.7%（P>0.05; the rheumatoid factor negative rate of the two groups were 76.7% and 70%（P>0.05）; before and after treatment, the differences of morning stiff joints time, tenderness index, swelling index were not obvious（P>0.05）; the occurrence rate of adverse reactions in the observation group was 6.67%, while that in the control group was 30%, and there was a significant difference between the two groups（P<0.05）. Conclusion： The comprehensive effect of applying different medication treatment of obstruction of collaterals type in rheumatoid arthritis is not obviously different, but the occurrence of complications is different.