| 引用本文:赵淑慧 杨彩梅.联合用药对阻络型类风湿关节炎的治疗分析[J].世界中医药,2014,9(03):. |
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| 联合用药对阻络型类风湿关节炎的治疗分析 |
| Analysis on Integrated Application of Traditional Chinese Medicine in Treating Rheumatoid Arthritis（RA）of Retention of Dampness-heat in Channel Type |
| 投稿时间：2013-07-24 |
| DOI：10.3969/j.issn.1673-7202.2014.03.016 |
| 中文关键词: 类风湿性关节炎 阻络型 中药 |
| English Keywords:Rheumatoid arthritis Retention of dampness-heat in channel Traditional Chinese medicine |
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| 中文摘要: |
| 目的：在辨病和辨证相结合的基础上，提出类风湿关节炎（Rheumatoid Arthritis，RA）的治疗原则，探讨不同中药联合治疗阻络型RA的疗效情况。方法：选取我院2010年12月至2012年12月收治的60例RA患者按照随机双盲对照试验设计方法将患者分为治疗组和对照组，每组30例。治疗组口服雷公藤多甙片和尪痹颗粒，对照组口服虎力散胶囊和复方风湿宁。比较治疗4周、8周后的临床疗效及治疗前、后关节的晨僵时间、压痛指数、肿胀指数、类风湿因子转阴情况及不良反应。结果：两组患者治疗4周、8周后，治疗组总有效率分别为83.3%、90.0%，对照组为80.0%和86.7%（P>0.05）；两组类风湿因子转阴率分别为76.7%和70.0%（P>0.05）；且两组治疗前、后关节的晨僵时间、压痛指数、肿胀指数差别都不明显（P>0.05）；而在不良反应方面，治疗组为6.67%，对照组为30.00%，两组比较，差异有统计学意义（P<0.05）。结论：不同联合用药方式治疗阻络型类风湿关节炎的综合疗效差别不明显，但药物不良反应的发生有不同。 |
| English Summary: |
| To assess clinical effectiveness and adverse effect of integrated application of TCM in treating Rheumatoid Arthritis（RA）of retention of dampness-heat in channel type. Methods： A total amount of 60 RA patients admitted in our hospital from December 2010 to December 2012 were divided into observation group and control group according to a double-blind randomized controlled trial design method, with 30 cases in each group. Patients in the observation group were treated with Tripterygium Wilfordii and Wangbi granule, while control group applied oral hulisan capsule and compound fengshining. Comparison was made in terms of the clinical therapeutic effect after 4 weeks and 8 weeks of treatment, the time of morning stiffness, joint pain index, swelling index, rheumatoid factor negative and adverse reaction before and after treatment. Results： After 4 and 8 weeks of treatment, the total effective rates of the observation group were 83.3% and 90%, and those of the control group were 80% and 86.7%（P>0.05; the rheumatoid factor negative rate of the two groups were 76.7% and 70%（P>0.05）; before and after treatment, the differences of morning stiff joints time, tenderness index, swelling index were not obvious（P>0.05）; the occurrence rate of adverse reactions in the observation group was 6.67%, while that in the control group was 30%, and there was a significant difference between the two groups（P<0.05）. Conclusion： The comprehensive effect of applying different medication treatment of obstruction of collaterals type in rheumatoid arthritis is not obviously different, but the occurrence of complications is different. |
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