The article explores the medication law of lung-intestine disease on different disease locations, and conducts data mining using association rules algorithm on lung-intestine disease medical cases in ancient literature. We found most cases describing sickness location at the stomach, which revealed that lung and large intestine performance was not only limited to sharing feedbacks of physiological and pathological information, but also sharing feedback synchronization of reactions to physiological and pathological information of other organs. As for pescription, Weijing decoction and Liujunzi decoction were applied the most, which indicated that damp heat pathogenesis and stomach lesions plays a key role in the lung and large intestine disease.