| 引用本文:李 建1 杨英伟1 刘恩顺2 苏景深2 李美凤1.通腑泻肺方对ALI/ARDS大鼠肺肠功能的影响[J].世界中医药,2014,9(04):. |
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| 通腑泻肺方对ALI/ARDS大鼠肺肠功能的影响 |
| Effects of Tongfu Xiefei Herbs on Lung and Large Intestinal Function in ALI/ARDS Rats |
| 投稿时间：2014-03-11 |
| DOI：10.3969/j.issn.1673-7202.2014.04.004 |
| 中文关键词: ALI/ARDS 肺功能 肠屏障功能 通腑泻肺 肺肠同治 |
| English Keywords:ALI/ARDS Lung function Intestinal barrier function Tongfu Xiefei Herbs Lung and large intestine concurrent therapy |
| 基金项目:国家重点基础研究发展计划(973计划)项目(编号：2009CB522702) |
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| 中文摘要: |
| 目的：观察通腑泻肺方对ALI/ARDS大鼠肺、肠功能的影响，为“肺与大肠相表里”理论提供实验证据。方法：健康SD大鼠30只，随机分为3组，正常组、模型组和治疗组，采用尾静脉注射油酸加内毒素方法造成ALI/ARDS模型，治疗组给予通腑泻肺中药，于实验第7天检测分析各组大鼠肺功能、肠屏障功能指标。结果：1）与正常组比较，模型组大鼠肺顺应性显著降低、吸气和呼气阻力显著升高（P<0.01），治疗后肺顺应性、吸气阻力有所改善；2）模型组大鼠肠组织中ocdudin蛋白表达较正常组明显降低（P<0.01）,治疗后显著升高（P<0.05）；SIgA含量较正常组明显升高（P<0.01），治疗后显著降低（P<0.05）。结论：除肺通气功能障碍外，ALI/ARDS大鼠肠屏障功能同时受损。通腑泻肺中药能改善肺通气障碍，保护肠黏膜屏障功能。 |
| English Summary: |
| To observe the effects of Tongfu Xiefei Herbs on lung and large intestinal function in ALI/ARDS rats, then provide experimental basis for ALI/ARDS lung and large intestine concurrent therapy. Methods： Thirty healthy SD rats were randomly divided into 3 groups： control group, model group, treatment group. The ARDS rats was established by intravenous injecting oleic acid plus endotoxin in caudal vein, and treatment group were treated with Tongfu Xiefei herbs. The indicators of lung and intestinal function in each group were observed after 7 days. Results：1）Compared with control group, the lung compliance of model group was obviously decreased; the aspiratory and expiratory resistance were obviously increased(P<0.01).The lung function of treatment group improved.2）Occludin protein expression in large intestine of model group were obviously decreased than that of control group(P<0.01),and were significantly increased after treatment(P<0.05).The SIgA of model group were obviously increased than control group(P<0.01),and were significantly decreased after treatment(P<0.05).Conclusion： With ventilation dysfunction, ALI/ARDS intestinal barrier function was damaged at the same time. Tongfu Xiefei herbs could improve the lung function and protect intestinal barrier function. |
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