To observe the effects of Tongfu Xiefei Herbs on lung and large intestinal function in ALI/ARDS rats, then provide experimental basis for ALI/ARDS lung and large intestine concurrent therapy. Methods： Thirty healthy SD rats were randomly divided into 3 groups： control group, model group, treatment group. The ARDS rats was established by intravenous injecting oleic acid plus endotoxin in caudal vein, and treatment group were treated with Tongfu Xiefei herbs. The indicators of lung and intestinal function in each group were observed after 7 days. Results：1）Compared with control group, the lung compliance of model group was obviously decreased; the aspiratory and expiratory resistance were obviously increased(P<0.01).The lung function of treatment group improved.2）Occludin protein expression in large intestine of model group were obviously decreased than that of control group(P<0.01),and were significantly increased after treatment(P<0.05).The SIgA of model group were obviously increased than control group(P<0.01),and were significantly decreased after treatment(P<0.05).Conclusion： With ventilation dysfunction, ALI/ARDS intestinal barrier function was damaged at the same time. Tongfu Xiefei herbs could improve the lung function and protect intestinal barrier function.