This article reviewed the ancient literatures of the "exterior-interior relation between lung and large intestine", and conducted data mining using modern information technology. Analysis was given on the disease location and symptoms. It is concluded that the lung and the large intestine have resonance phenomena in the expression of physiological and anthological information. And the resonance phenomenon is caused by other organs involved in action. Among them, the spleen and the liver are most closely related, which indicates that during clinical differentiation on lung and large intestine disease, attention shall also be given to other organs.