To observe the effect of modified Xiaoyao granules on the serum IGF-1 of tumor patients, and explore the relationship between tumor related depression and serum IGF-1. Methods： Comparison before-after study, and the level of serum IGF-1 was observed. A total of 64 patients with cancer related depression were given continuous treatment of 2 courses (14 days for a course). Results： The serum IGF-1 level of cancer-related depression patients before treatment was obviously higher than that of normal small samples; after 28 days treatment, serum IGF-1 level of patients decreased, with statistical significance, P<0.05(P=0.041). Conclusion： Modified Xiaoyao granules can reduce IGF-1 level. Verification of IGF-1 and cancer related depression is positively relevant.